专利名称 ---【 Retinoids and methods of use of same 】

基本信息
申请号
US48706195A
申请日
1995.06.07
公开(公告)号
US5716982A
公开(公告)日
1998.02.10
申请(专利权)人
中国科学院上海药物研究所
申请人地址
发明人
HAN RUI ; XU SHI-PING; 专利类型 US
摘要
New retinoid compounds, as coumarin retinoids and/or purine retinoids and compositions thereof, are provided which exhibit therapeutic and/or biological activity on cancer or precancer cells, as well as to methods of use of same.
主权项

 

IPC信息
IPC主分类号
C07D311/12
IPC分类号
C07D311/12;C07D311/14;C07D311/16;A61K31/37

 

法律状态信息
法律状态公告日
1998.02.10
法律状态
授权 法律状态信息
授权

 

代理信息
代理机构名称
代理人姓名

 

被引专利信息
引用阶段 被引时间 专利号 申请人 公开时间
SEA null CA1127170A BASF AG 19820706
SEA null US3541097A BEYERLE RUDI, et al 19701117
SEA null US4126693A GANDER ROBERT J, et al 19781121
SEA null US4144336A BOLTZE KARL-HEINZ, et al 19790313
SEA null US4151179A APPLETON RICHARD A [GB], et al 19790424
SEA null US4190594A GANDER ROBERT J [US], et al 19800226
SEA null US4310546A GANDER ROBERT J 19820112
SEA null US4323581A GANDER ROBERT J 19820406
SEA null US4385175A JUST GEORGE [CA], et al 19830524
SEA null US4523042A LOEV BERNARD [US], et al 19850611
SEA null US4602034A BRIET PHILIPPE [FR], et al 19860722
SEA null US4713465A KRAEMER JOSEF [DE], et al 19871215
SEA null US4783533A BRIET PHILIPPE [FR], et al 19881108
SEA null US4960908A ITO NORIKI [JP], et al 19901002
SEA null US5096713A PHILIPPE MICHEL [FR], et al 19920317
SEA null US5096924A ISHIZUKA MASAAKI [JP], et al 19920317
SEA null US5116954A BRIET PHILIPPE [FR], et al 19920526
SEA null US5124083A SHEALY Y FULMER [US] 19920623
SEA null US5141746A FLEURY YVETTE [CH], et al 19920825

 

被引非专利信息
引用阶段 被引时间 被引文档类型 被引文档信息
SEA null a Shiping Xu et al., CA 96:123037, 1982.
SEA null a Shiping Xu et al., Yaoxue Xerbao (1981), 16(9), 678 86.
SEA null a S. Shibata, Anti tumorgenic chalcones, Stem Cells, vol. 12:44 62, 1994.
SEA null a Srivastava et al. Effect of quercetin on serine/threonine and tyrosine protein kinase, Plant Flavonoids in Biology and Medicine: Biochemical, Pharmacological and Structure Activity Relationships, pp. 315 318, 1986.
SEA null a Piantelli et al. Type II Estrogen Binding Sites and Antiproliferative Activity of Quercetin in Human Meningiomas, Cancer, vol. 71:193 199, 1993.
SEA null a B. Havsteen, Flavonoids, A Class of Natural Products of High Pharmacological Potency, Biochemical Pharmacology, vol. 32:1141 1148, 1983.
SEA null a Chae et al. Effects of synthetic and naturally occurring flavonoids on benzo a pyrene metabolism by hepatic microsomes prepared from rats treated with cytochrome P 450 inducers, Cancer Letters, vol. 60, pp. 15 24, 1991.
SEA null a M.E. Marshall et al. Growth inhibitory effects of coumarin (1,2 benzopyrone) and 7 hydroxycoumarin on human malignant cell lines in vitro, J. Cancer Res.&Clin. Oncol., vol. 120, pp. S3 S10, 1994.
SEA null a Bibby et al. Flavone acetic acid from laboratory to clinic and back, Anti Cancer Drugs, vol. 4, pp. 3 17, 1993.
SEA null a Jing et al. Structural Requirements for Differentiation Induction and Growth Inhibition of Mouse Erythroleukemia Cells by Isoflavones, Anticancer Research, vol. 15, pp. 1147 1152, 1995.
SEA null a Blazsek et al., Retinoic acid in mono or combined differentiation therapy of myelodysplasia and acute promyelocytic leukemia, Biomed&Pharmacother, vol. 45, pp. 169 177, 1991.
SEA null a Abstract Cassady et al., Recent Advances in the Discovery of Potential Cancer Chemopreventive Agents, Abstract Collection of International Symposium on Recent Advances in Chemistry and Molecular Biology of Cancer Research, Beijing, China, pp. 5 6, 1991.
SEA null a Castaigne et al., All Trans Retinoic Acid as a Differentiation Therapy for Acute Promyelocytic Leukemia. I. Clinical Results, Blood, vol. 76, No. 9, pp. 1704 1709, 1 Nov. 1990.
SEA null a Chomienne et al., All Trans Retinoic Acid in Acute Promyelocytic Leukemias. II. In Vitro Studies: Structure Function Relationship, Blood, vol. 76, No. 9, pp. 1710 1717, 1 Nov. 1990.
SEA null a Chomienne et al., Structure Activity Relationships of Aromatic Retinoids on the Differentiation of the Human Histiocytic Lymphoma Cell Line U 937, Leukemia Research, vol. 10, No. 11, pp.1301 1305, 1986.
SEA null a Clarkson, Retinoic Acid in Acute Promyelocytic Leukemia: The Promise and the Paradox, Cancer Cells, vol. 3, No. 6, pp. 211 220, Jun. 1991.
SEA null a Dawson et al., Aromatic Retinoic Acid Analogues. Synthesis and Pharmacological Activity, Journal of Medicinal Chemistry, vol. 24, No. 5, pp. 583 592, 1981.
SEA null a Dawson et al., Conformationally Restricted Retinoids, J. Med. Chem., vol. 27, No. 11, pp. 1516 1531, 1984.
SEA null a Degos, All trans retinoic acid ( ATRA ) therapeutical effect in acute promyelocytic leukemia, Biomed&Pharmacother, vol. 46, pp. 201 209, 1992.
SEA null a Abstract Du et al., Comparison of Toxicities of 4 ( ethoxycarbophenyl ) Retinamide and Some Other Retinoids, Institute of Materia Medica, vol. 18, No. 5, 1982.
SEA null a Edwards et al., Chalcones: A New Class of Antimitotic Agents, J. Med. Chem., vol. 33, pp. 1948 1954, 1990.
SEA null a Nair et al., Novel Coumarins as Potential Anticarcinogenic Agents, Carcinogenesis, vol. 12, No. 1, pp. 65 69, 1991.
SEA null a Preuss Ueberschar et al., Drug Res., vol. 34, pp. 1305 1313, 1984.
SEA null a Smith et al., Retinoids in Cancer Therapy, Journal of Clinical Oncology, vol. 10, vo. 5, pp. 839 864, May 1992.
SEA null a Egan et al., The Pharmacology, Metabolism, Analysis, and Applications of Coumarin and Coumarin Related Compounds, Drug Metabolism Reviews, vol. 22, No. 5, pp. 503 529, 1990.
SEA null a Abstract Han et al., Effects of S86019, An Active Component From Puralia Lobata, On Cell Differentiation and Cell Cycle Traverse of HL 60 Cells, Chinese Journal of Cancer Research, vol. 2, No. 3, pp. 51 53, 1990.
SEA null a Han et al., Evaluation of N 4 ( Hydroxycarbophenyl ) Retinamide as a Cancer Prevention Agent and as a Cancer Chemotherapeutic Agent, In Vivo, vol. 4, pp. 153 160, 1990.
SEA null a Harvey et al., A New Coumarin Synthesis and Its Utilization for the Synthesis of Polycyclic Compounds with Anticarcinogenic Properties, J. Org. Chem., vol. 53, No. 17, pp. 3936 3943, 1988.
SEA null a Harvey et al., A New Chromone and Flavone Synthesis and Its Utilization for the Synthesis of Potentially Antitumorigenic Polycyclic Chromones and Flavones, J. Org. Chem., vol. 55, No. 25, pp. 6161 6166, 1990.
SEA null a Abstract Ho et al., Synthesis and Structure Activity Relationship of Potential Inhibitors of Benzo a pyrene Carcinogenesis, Abstract Collection of International Symposium on Recent Advances in Chemistry and Molecular Biology of Cancer Research, Beijing, China, pp. 68 69, Jul. 1991.
SEA null a Abstract Jing et al., Differentiation of B16 Melanoma Cells Induced by Daidzein, Chinese Journal of Pharmacology and Toxicology, vol. 6, No. 4, pp. 278 280, Nov. 1992.
SEA null a Kizaki et al., Differentiation Inducing Agents in the Treatment of Myelodysplastic Syndromes, Seminars in Oncology, vol. 19, No. 1, pp. 95 105, Feb. 1992.
SEA null a Kagechika et al., Retinobenzioc Acids. 3. Structure Activity Relationships of Retinoidal Azobenzene 4 carboxylic Acids and Stilbene 4 carboxylic Acids, J. Med. Chem., vol. 32, pp.1098 1108, 1989.
SEA null a LoCoco et al., Molecular Evaluation of Response to All Trans Retinoic Acid Therapy in Patients With Acute Promyelocytic Leukemia, Blood, vol. 77, No. 8, pp. 1657 1659, 15 Apr. 1991.
SEA null a Middleton, Jr., Effects of Flavonoids on Immune and Inflammatory Cell Functions, Biochemcial Pharmacology, vol. 43, No. 6, pp. 1167 1179, 1992.
SEA null a Newton et al., Structure Activity Relationships of Retinoids in Hamster Tracheal Organ Culture, Cancer Research, vol. 40, pp. 3413 3425, Oct. 1980.
SEA null a Sato et al., Functional Studies of Newly Synthesized Benzoic Acid Derivatives: Identification of Highly Potent Retinoid Like Activity, Journal of Cellular Physiology, vol. 135, pp. 179 188, 1988.
SEA null a Shealy et al., Terminal Bifunctional Retinoids. Synthesis and Evaluation Related to Cancer Chemopreventive Activity, J. Med. Chem., vol. 31, pp. 1124 1130, 1988.
SEA null a Skrede et al., Retinyl Esters in Chylomicron Remnants Inhibit Growth of Myeloid and Lymphoid Leukaemic Cells, European Journal of Clinical Investigation, vol. 21, pp. 574 579, 1991.
SEA null a Abstract Song et al., Differentiation of Human Promyelocytic Leukemia ( HL 60) Cells Induced By New Synthetic Retinoids 4 ( ethoxycarbophenyl ) Retinamide and 4 ( hydroxycarbophenyl ) Retinamide, Institute of Materia Medica, Chinese Academy of Medical Sciences, pp. 576 581, 1984.
SEA null a Warrell, Jr., All Trans Retinoic Acid: What Is It Good For Journal of Clinical Oncology, vol. 10, No. 11, pp. 1659 1661, Nov. 1992.
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