专利名称 ---【 SPARSTOLONIN B DERIVATIVE AND PREPARATION METHOD THEREFOR AND USE THEREOF 】

基本信息
申请号
WO2016CN72416
申请日
2016.01.28
公开(公告)号
WO2016127812(A1)
公开(公告)日
2016.08.18
申请(专利权)人
中国科学院成都生物研究所
申请人地址
发明人
SUN, Jian;WANG, Chao; 专利类型 WO
摘要
The present invention relates to a natural product sparstolonin B derivative and a preparation method therefor and use for preparing anti-tumor drugs. The structural formula of the derivative is as follows, wherein R is hydrogen, C1-6 alkyl, C3-6 cycloalkyl, C5-10 aryl, pyridyl, CnH2nX, OR1 or NR2R3; n is 1-6, X is vinyl, acetenyl, C5-10 aryl, azo-aryl comprising 1 to 4 nitrogen atoms and 1 to 5 carbon atoms, hydroxyl, C1-4 alkoxyl, amino, N, N-biC1-4 alkyl amino, carboxyl, acylamino, sulphonylamino, C1-4 alkoxycarbonyl, cyano or nitryl; R1 is hydrogen, C1-4 alkyl, benzyl or methoxyl benzyl; and R2 and R3 are respectively hydrogen, C1-4 alkyl, benzyl, methoxyl benzyl or R2 and R3 jointly form a 4-7 membered ring with N atoms. The sparstolonin B derivative in the present invention is used for anti-tumor drugs, and the compound in the present invention is novel in structure, has relatively good druggability and has relatively high activity of inhibiting tumor cell growth, and has a simple and convenient preparation method and is easy to operate and amplify.
主权项

 

IPC信息
IPC主分类号
C07D491/06
IPC分类号
C07D491/06;A61P35/00

 

法律状态信息

 

代理信息
代理机构名称
代理人姓名
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